Yep, and surviving longer increases cancer rates. Cancer used to be a death sentence, now it is far less so. Many cancers which were a short time from death at diagnosis are now routine to remove or fix. Others that were soon fatal have 5 year survival over 90%, and some are even higher.

We haven’t cured cancer just like we haven’t cured industrial accidents, but honestly, so few people are eaten by hungry machines and left disfigured that it is likely you know less than a handful. Not cured but reduced to a much more manageable level.

The crazy thing is we actually do have things that work in humans but not in mice. Mice are omnivores and are very different in terms of optimal energy state. They tend to run in glucose more easily than on fat and their whole biology is built to be small and fast, with short life spans.

Checking how DNA repair works in an animal which lives for maybe 2 years is great for understanding DNA repair in short lived organisms, but we have tk repair damage for 50 times as long. It is just so much more complex and requires such different tools when you switch from maybe 2 years to maybe 80 years, it really isn’t sane to assume it will all carry over.

Now for an accute toxin, say tobacco, sure, some things work just fine. There is not a huge difference between humans and mice when subjected to cyanide or arsenic. Being crushed by a falling piano is going to kill both of us. But a chronic poison? That will take decades to kill? That is very different. We can shed cells in a different way to how they can. We have more mass to store things. We have more energy storage. We have bigger kidneys with more opportunities for filtering. We are different.

When we enter ketosis we have some fairly significant cancer responses. When we maintain fasting for 5+ days we have a fairly large bump in autophagy, a state where the body kills off and recycles damaged cells. This state can cause some types of cancer to be more obvious to our immune systems and allow the tumor to be attacked. In some cases otherwise inoperable tumors can be removed after shrinking them through fasting. This does not replicate in mice. So yes, some treatments (not cures because that doesn’t really apply) do work in humans and not in mice.

As a fellow Aussie I share your conclusion, though the Made in Australia plan from the Albanese government seems like it could change the game. Producing solar panels here would make purchasing them cheaper even if just from the shipping costs. Add the federal investment and the creation of demand and it should get cheaper again.

Now I do worry about things going the way of the NBN, starting with a goal of future proof fibre to the home being chipped away by the LNP until it was a small upgrade on internet service funded by the government but not anything like the goal. I want good green tech, not just barely solar sometimes.

Coal is dying as an investment but existing coal plants will likely run for a long while. Overall demand for energy is rising, the new demand is being met mostly with renewables, but there is a small amount of that increase that is being met by a small increase in coal usage. As renewable manufacture gets faster and more efficient I expect the coal growth will reverse, but it is all about when. If it happens quickly we have less apocalyptic damage. If it happens slowly then we will be more fucked.

Solar is far and say the cheapest form of new energy to roll out. Wind is a not so close second. Coal is getting more expensive by the day. The only reason to roll out coal is insufficient production of solar and wind. It takes time to increase manufacturing capacity but we are getting there and we can do this.

I am reminded of hospital acquired infections being treated like car crashes or plane crashes.

Car crashes kill massive numbers of people each year, just under 5 per 100,000 people per year here in Australia. That is way down and we are quite low globally, with the EU overall around 9 and 14 for the USA. We have taken fairly agressive steps to curb road deaths and made real progress, but a certain number of deaths is accepted as necessary. A crash is investigated for fault attribution and insurance but not for preventing a repeat.

Plane crashes are totally different. If something caused a plane crash we figure it out, make a mitigation, and make it never happen again. Flying is one of the safest modes of transport and it keeps getting safer.

In hospitals most of them had the car crash mentality for hospital acquired infections. A hospital putting in a plane crash mentality investigator for their Infection Prevention chair will have very different outcomes, especially over time. Someone got an infection from bad clean technique? Make it a checklist item. Someone still got another infection? Change gloving technique so that you wear two layers and only touch the outer gloves with clean inner gloves. Another case? Have a second staff member assist with your donning of PPE and going through the checklist. Each step reduces the risk, each mitigation makes everyone safer. Eventually you have so few infections it is hard to test new processes.

For anyone wondering edgydoc.com is the site for the aforementioned doctor and he is a blast. But yeah, if you treat a consequence as a cost of doing business nothing changes. If you make failure an existential risk you can eliminate problems. Corporations are run by people. Those people should be accountable for the crimes of the company.