Strong statement. The brain can run on ketones just fine, it’s constantly titrating energy consumption from different sources. You might say the brain uses glucose first as a priority, but that is also true for alcohol.
Fat can be broken down into glucose, though
Not really a complete statement, gluconeogenesis requires more inputs then just fat, so of the glucose produced only 15% of the energy is coming from fat.
There is a 1972 paper that demonstrates normal functioning after prolonged fat adaptation, it’s a great read, but this specifically speaks to brain glucose utilization - https://doi.org/10.1172/JCI107095
Note how I said it can be converted to glucose. Note how all you did was describe how it can be converted to glucose. Nowhere did I say that process took nothing. Nowhere did I say it needs only glucose.
Just like your car doesn’t only need gas to function, and can technically ‘run’ on other things like pure alcohol.
There is a 1972 paper that demonstrates normal functioning after prolonged fat adaptation, it’s a great read, but this specifically speaks to brain glucose utilization - https://doi.org/10.1172/JCI107095
It actually can run mostly on fat, it’s just that most people are eating massive constant streams of glucose all the time
At birth, and during breastfeeding, human brains are running on fat
No it cannot run on fat.
Fat can be broken down into glucose, though. It still takes a conversion or several to get to glucose from fat.
Strong statement. The brain can run on ketones just fine, it’s constantly titrating energy consumption from different sources. You might say the brain uses glucose first as a priority, but that is also true for alcohol.
Not really a complete statement, gluconeogenesis requires more inputs then just fat, so of the glucose produced only 15% of the energy is coming from fat.
There is a 1972 paper that demonstrates normal functioning after prolonged fat adaptation, it’s a great read, but this specifically speaks to brain glucose utilization - https://doi.org/10.1172/JCI107095
Note how I said it can be converted to glucose. Note how all you did was describe how it can be converted to glucose. Nowhere did I say that process took nothing. Nowhere did I say it needs only glucose.
Just like your car doesn’t only need gas to function, and can technically ‘run’ on other things like pure alcohol.